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In an embodiment, the substituted tetracycline compound is a substituted tetracycline (eg, generally, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl, R 5 is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); substituted doxycycline (eg, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is ritonavir neuropathy 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); substituted minocycline (eg, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms and R 7 is dimethylamino) or substituted sancycline (wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms). Some hypertensive patients with no apparent ritonavir oral solution formulation renal disease have developed increases in blood urea and serum creatinine when lisinopril has been given concomitantly with a diuretic.
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